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For example, in single dose studies, the effect of feeding had a greater influence on the rate of absorption of the divalproex sodium tablet (increase in Tmax from 4 to 8 hours) than on the absorption of the divalproex sodium sprinkle capsules (increase in T max from 3.3 to 4.8 hours)

Rudmans publication, a lot more research has been undertaken and doses have been reduced somewhat

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Serum integrative omics reveals the landscape of human diabetic kidney disease